Luminal Injection of Hydrogen-Rich Solution Attenuates Intestinal Ischemia-Reperfusion Injury in Rats
نویسندگان
چکیده
منابع مشابه
Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats.
BACKGROUND Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia-reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic ef...
متن کاملHydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.
Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries. This paper studied the effect of hydrogen-rich saline, which was easier for clinical application, on the intestinal I/R injury. Model of intestinal I/R injury was induced in male Sprague-Dawley rats. Physiological saline, hydrogen-rich saline or nitroge...
متن کاملHydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
OBJECTIVE Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. METHODS Male Sprague-Dawley rats (n=30, 200-220g) were divided randomly into three experimental groups: sham o...
متن کاملThe preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar rats
Objective(s): Intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. Materials and Methods: Animals were randomized into three gro...
متن کاملThe Protective Effect of Orally Administered Amlodipine against Intestinal Ischemia-Reperfusion Injury in Rats
Objective- This study investigated the effect of amlodipine on intestinal ischemia-reperfusion injury in ratsDesign-Experimental studyAnimals-Fifteen male Sprague-Dawly rats weighing 200-220gProcedure- Rats were randomly divided into 3 groups: IR group (operation with clamping), sham group (operation without clamping), and IRA group (operation with clamping and 5mg/kg amlodipi...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2015
ISSN: 0041-1337
DOI: 10.1097/tp.0000000000000510